Recommended Methods current

No. 63 - Determination of Tobacco Specific Nitrosamines in Cigarette Mainstream Smoke - GC-TEA Method

(CRM developed into ISO 22303; ISO 22304)

January 2019 - second edition Ref. SMA-163-CRM-63

This Recommended Method is applicable to the determination of four Tobacco Specific Nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke. The determined TSNAs are: N-Nitrosonornicotine (NNN), N-Nitrosoanabasine (NAB), N‑Nitrosoanatabine (NAT) and 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK).

The described method is specified using ISO 3308 smoking parameters, but is technically compatible with other smoking regimes.

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