This Recommended Method is applicable to the determination of nicotine degradants and impurities in nicotine pouches. Nicotine pouches, or white pouches, are oral tobacco products that contain tobacco derived nicotine, but not tobacco leaf. The nicotine degradants included in this Recommended Method are: anatabine, anabasine, nicotine-N’-oxide, myosmine, β-nicotyrine, cotinine, and nornicotine.