TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 28
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans.
(1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Duke University, Durham, NC, USA
The metabolites of the tobacco-specific nitrosamine NNK form DNA adducts in animal models. A previous report indicates that NNK could cause damage to the mitochondrial as well as nuclear genome in rats (Stepanov and Hecht, 2009 Chem. Res. Toxicol....