Sixty C3F samples of flue-cured tobacco leaves were collected from Zhumadian to analyze the relationship between physical-chemical indexes and full flavor style degree of leaves with correlation analysis and stepwise regression analysis. The results showed that: 1) the full flavor style degree of leaves significantly positively correlated with leaf thickness, potassium, megastigmatrienone A, megastigmatrienone B, and megastigmatrienone C; extremely significantly positively correlated with volatile base, kaempferol-3-rutinoside, furfural, furfural alcohol, 5-methyl furfural, and megastigmatrienone D; while significantly negatively correlated with reducing sugar; extremely significantly negatively correlated with linalool, farnesylacetone, geranyl acetone, ?-ionone, 2-acetyl furan; 2) there was an extremely significant regression relationship between full flavor style degree of leaves and furfural, 5-methyl furfural, 2-acetyl furan, geranyl acetone, which were the major components affecting the full flavor style degree of leaves, and determined about 88.7% of the changes of full flavor style degree of leaves.