Crop protection has become increasingly the focus of several international regulatory agendas. In particular, initiatives to ensure that the use of registered Crop Protection Agents (CPAs) and certain residues on agricultural commodities do not exceed recognised limits at points from field to finished product are relevant. Homologa™, the Global Crop Protection Database, has become an essential monitoring tool to assist farmers, commodity suppliers, traders, manufacturers and governmental officials with their CPA management strategies. Thus, reflecting the ever-changing dynamics of the global tobacco industry, this presentation will focus mainly on the increasing importance of monitoring registration status of CPAs when growing and sourcing tobacco materials. Several strategic elements will be presented and discussed to illustrate the challenges faced by industry stakeholders with respect to tobacco leaf integrity, procurement and overall product stewardship while operating under increasingly stringent regulations.