In some European regions a number of tobacco varieties, above all modern American tobacco varieties, are seized by a lot of dangerous virus diseases with losses in yield. Breeding of resistant varieties with the same flavour and desirable properties need a lot of time. In this situation antiphytoviral substances for chemical control measurements would mean a major advance. A survey is made of the most efficient antiphytoviral compounds, which have been developed during the last years. Results of the application of antiphytoviral agents against tobacco viruses are reported. Highest efficiency was obtained by combining two or three antiphytoviral principles in one antiphytoviral preparation, one of them being 2,4-dioxo-hexahydro-1,3,5-triazine. Further progress in effectiveness was obtained by granulating antiphytoviral materials, which provide protection all over the year with one application during planting. The expenses of an effective antiphytoviral chemotherapy will scarcely exceed other measurements of plant protection.