The Rogue® Longitudinal Switching Study assessed oral nicotine product use and switching behaviors among 1,863 adult cigarette smokers in the U.S. over 6 months. The study determined the associations between use of Rogue® Nicotine Products (RNP) and cigarette reduction and quitting. Participants were provided their choice of RNP Pouch (6mg), Gum (4mg), and/or Lozenge (4mg) in 14 flavors and were free to use or not use the products at their discretion. Combustible Cigarette (CC), and other tobacco and nicotine product (TNP) use were assessed at enrollment, and again (along with RNP use) at 1-, 2-, 4-, and 6-month intervals. Among 1,393 participants who completed the study, RNP use was associated with a statistically significant reduction in CC use at 6-months, with 720 participants reducing their cigarettes per day (CPD) by 25-99% (51.7%, p<0.001) and 524 participants reducing by 50-99% (37.6%, p<0.001). RNP use was also significantly associated with CC quitting, with 185 participants (13.3%, p<0.001) quitting at 6-months after baseline. Participants who used more RNP per day smoked fewer cigarettes than those who used less RNP (p<0.001), both overall and for each RNP form (pouch, gum, and lozenge). This study conducted in a near real-world setting, provides evidence that switching to use of RNP may have beneficial effects in helping CC users significantly reduce or quit smoking.